Thermal-sprayed Silver-containing Hydroxyapatite Coating in a Rat Femoral Model: Analysis of the Initial Fixation
نویسندگان
چکیده
Introduction: The degree of osseointegration determines the long-term survival and favorable outcomes of orthopedic implant use. Initial fixation is influenced by a number of factors. Hydroxyapatite (HA) coating has a good osteoconductive property and sealing effect on peri implant migration of particles that lead to osteolysis. Furthermore, HA-coated implants show desirable midterm clinical results. Infection prevention is another important factor that influences long-term results. Postoperative infections sometimes occur despite systemic prophylaxis, necessitating surgical treatment. This complication is not only difficult for patients and surgeons but also increases medical costs. Thus, the availability of an implant that has both osteoconductive and antibacterial properties is required. We previously developed an antibacterial coating with Ag-containing HA (Ag-HA) that releases Ag ions to achieve high antibacterial activity and low cytotoxicity in vitro [1]. Antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) has been shown in vitro [2], in a subcutaneous rat model [3], and in a rat tibia model [4]. In addition, the Ag-HA coating has properties of both Ag and HA and shows good biocompatibility and osteoconductivity in rat tibiae [5]. However, a direct mechanical assessment has not been performed to date. Thus, the aim of this study is to evaluate the initial fixation of Ag-HA coating on titanium (Ti) in terms of shear strength.
منابع مشابه
Toxicity In Vivo Of Thermal-sprayed Silver Containing Hydroxyapatite Coating In The Rat Tibia
متن کامل
Acute and Subacute Toxicity In Vivo of Thermal-Sprayed Silver Containing Hydroxyapatite Coating in Rat Tibia
To reduce the incidence of implant-associated infection, we previously developed a novel coating technology using hydroxyapatite (HA) containing silver (Ag). This study examined in vivo acute and subacute toxicity associated with the Ag-HA coating in rat tibiae. Ten-week-old rats received implantation of HA-, 2% Ag-HA-, or 50% Ag-HA-coated titanium rods. Concentrations of silver in serum, brain...
متن کاملA prospective randomized study comparing electrochemically deposited hydroxyapatite and plasma-sprayed hydroxyapatite on titanium stems
BACKGROUND AND PURPOSE Plasma-sprayed hydroxyapatite (HA) is a successful coating for fixation of uncemented femoral stems. There may be alternative coatings with advantages in bone remodeling and transport of bone-active substances. We investigated whether an electrochemically deposited hydroxyapatite, Bonemaster (BM), might be a safe alternative in total hip arthroplasty. Our hypothesis was t...
متن کاملBone Tissue Response to Plasma Sprayed Hydroxyapatite Coatings: An In Vivo Study on Rabbit Femoral Condyles
In this study, hydroxyapatite was coated on titanium substrates by plasma spraying process. A well-known porous and lamellar microstructure was found in the lateral a...
متن کاملThermal processing of hydroxyapatite for coating production.
Thermally processed hydroxyapatite coatings used on dental implants and hip prostheses for enhanced fixation may typically consist of a number of chemical and structural phases. These phases affect coating performance and tissue attachment. Hydroxyapatite was plasma sprayed to examine the phase evolution during processing. Coatings were examined with X-ray diffraction and elemental analysis. Re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014